Protocolo para Sarcomas de Partes Blandas No-Rabdomiosarcoma localizados






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Venous/lymphatic invasion

Present

Absent

Cannot be assessed

Grading of Soft Tissue Sarcoma

Use FNCLCC system

Molecular characterisation

Please note: if molecular characterisation has been undertaken, then this should either be

included in the main body of the report or set out as a separate report. A copy of this report

needs to be sent to the national coordinator together with the copy of the histology report

and form.

Post-chemotherapy specimens

Same procedure as above. It is important to specift the following:

% of necrosis

% of fibrosis

% of viable tumour

EpSSG NRSTS 2005 protocol

165

8. MATERIAL TO BE SENT TO NATIONAL CO-ORDINATORS

1. In the case of trucut biopsies, both primary and post-chemotherapy, 1 H&E and 15uss

(or the loan of the block).

2. In the case of open biopsies/resected specimens, including post-chemotherapy

specimens – 1 H&E from each block, and at least 20 uss from representative block(s) (or the loan

of the blocks).

3. The uss should be on coated slides to be used for immunohistochemistry.

4. It is important that material from primary biopsy/resection and post-chemotherapy

biopsy/resection and biopsy/resection of metastases is sent for review by the local co-ordinator.

5. If in the case of a very small biopsy there is not sufficient material left in the block, please

send 1 H&E to be kept by the local co-ordinator and the original H&E and immunohistochemistry

slides, which will be returned.

6. It is understandable that these requests create more work for the pathologist and laboratory

staff. Therefore, it is possible to send blocks to the local co-ordinator. These will be returned.

7. The local pathologist report and the form need to be sent with the slides.

8. The national co-ordinators and panel of pathologists are offering real time review.

9. The slides/block and forms should be sent directly to the national co-ordinators.

NB: It is very important that we collect prospectively the results of the molecular diagnostics. Each

oncology centre/pathology lab. should ensure that, if this cannot be carried out in their centre/lab.,

arrangements should be made with other laboratories to ensure that, whenever possible, molecular

diagnostics are carried out.

In cases where there is a discrepancy between the local pathologist’s evaluation and the molecular

diagnostic result, then rapid pathology review is recommended. All results will be sent to the

referring pathologist and in case of discrepancy cases will be discussed with the referring

pathologist.

EpSSG NRSTS 2005 protocol

166
Bibliografía:
1. Ruth Ladenstein et al. Synovial Sarcoma of Childhood and Adolescence. Cancer 1993,

Vol.71:11; p3647-55.
2. Andrew L. Folpe et al. Poorly Differentiated Synovial Sarcoma. Am.J.Surg.Path.1998,

22(6):763-682.
3. D. Ashley Hill et al. Real-Time Polymerase Chain Reaction as an aid for the Detection of SYTSSX1

& SYT-SSX2 Transcripts in Fresh and Archival Paediatric Synovial Sarcoma. Paed.&

Devel. Path 2002 ,6:24-34.
4. Louis Guillon et al. Histologic Grade, but not SYT-SSX Fusion Type, is an Important

Prognostic Factor in Patients with Synovial Sarcoma. J. Clin.Oncol. 2004;Vol.22, No.20: 4040-50.
5. Fisher C. Synovial Sarcoma. Ann.Diagn.Pathol.1998; 2: 401-21.
6. Schmidt D. et al. Synovial Sarcoma in Children and Adolescents. A report from the Kiel

Paediatric Tumour Registry. Cancer 1991; 67:1667-72.
7. Jean Michel Coindre et al. Reproducibility of a Histopathologic Grading Syetem for Adult Soft

Tissue Sarcoma. Cancer 1986;Vol.58: 306-309.
8. Bruce R. Parvel et al. Undifferentiated Sarcomas of Children: Pathology and Clinical Behaviour

An Intergroup Rhabdomyosarcoma Study. Med.Pediatr.Oncol.1997;29:170-80.
9. Agnes S. Chan et al. Variant EWS-WT1 Chimeric Product in the Desmoplastic Small Round

Cell Tumour. Pediatr.Dev.Pathol. 1999;2:188-92.
10. Helen Liaps et al. p53 and Ki-67 Proliferating Cell Muscle Antigen in Benign and Malignant

Peripheral Nerve Sheath Tumours in Children. Pediatr.Dev.Pathol. 1999;2:377-84.
11. Coffin C.M. et al. Extrapulmonary Inflammatory Myofibroblastic Tumours. A

Clinicopathologic and Immunohistochemical Study of 84 cases. Am.J.Surg.Pathol.1995; 19: 859-

72.
12. Coffin C.M. et al. Inflammatory Myofibroblastic Tumour, Inflammatory Fibrosarcoma and

Related Lesions: An Historical Review with Differential Diagnostic Considerations.

Semin.Diagn.Pathol. 1998;15:102-10.
13. Liebermann P.H. etal. Alveolar Soft Part Sarcoma. Cancer 1989; 63:1-13.
14. Ondonez N.G. Alveolar Soft Part Sarcoma: A Review and Update. Adv.Anat.Pathol.1999;

6:125-39.
15. Bunke A.P. et al. Intra-abdominal Fibromatosis: A Pathologic Analysis of 130 Tumours with

comparison of Clinical Subgroups. Am.J.Surg.Pathol.1990;14:335-41.

16. Lack E.E. Leiomyosarcoma in Childhood: A Clinical and Pathologic Study of 10 cases.

Paed.Pathol.1986; 6:181-97.
17. Swanson P.E. et al. Leiomyosarcoma of Somatic Soft Tissues in Childhood: An

Immunohistochemcal Analysis of 6 cases with Ultrastructural Correlation. Hum. Pathol.1991; 22:

569-77.
18. de Saint Aubain Somerhausen N. et al. Leiomyosarcoma of Soft Tissues in Children:

Clinicopathologic Analysis of 20 cases. Am.J.Surg.Pathol.1999; 23:755-63.


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